AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer.
Jackstadt R, Röh S, Neumann J, Jung P, Hoffmann R, Horst D, Berens C, Bornkamm GW, Kirchner T, Menssen A, Hermeking H.
Jackstadt R, et al.
J Exp Med. 2013 Jul 1;210(7):1331-50. doi: 10.1084/jem.20120812. Epub 2013 Jun 10.
J Exp Med. 2013.
PMID: 23752226
Free PMC article.
Besides many genes involved in the control of proliferation, the AP4 target genes included markers of stemness (LGR5 and CD44) and epithelial-mesenchymal transition (EMT) such as SNAIL, E-cadherin/CDH1, OCLN, VIM, FN1, and the Claudins 1, 4, and 7. Accordingly, activation …
Besides many genes involved in the control of proliferation, the AP4 target genes included markers of stemness (LGR5 and CD44) and epithelia …